InterPro domain: IPR044692

This family includes WPP domain-containing proteins 1/2/3 (also known as MFP1 attachment factors 1/2/3), homologues of the MFP1 attachment factor 1 (MAF1), a plant-specific nuclear envelope (NE)-associated protein first identified in tomato. These proteins are NE-associated proteins containing a WPP domain predicted to consist of a beta-strand and three alpha-helices, sufficient for NE targeting [ 1 , 2 ]. These proteins regulate the mitotic activity in roots and play a role with HSP70-1 in facilitating WIT1 (WPP domain-interacting tail-anchored protein 1) nuclear envelope targeting [ 3 ].

1. Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division. Plant Cell 16, 3260-73
2. WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Plant Physiol 151, 142-54