InterPro domain: IPR044668

This entry includes gamma-glutamyl-gamma-aminobutyrate hydrolases and related proteins mostly from bacteria, archaea and plants, including PuuD from E. coli and Cj1417c from Campylobacter jejuni. They belong to the peptidase C26 family. PuuD is involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma-aminobutyrate [ 1 , 2 ]. Cj1417c catalyses the hydrolysis of CDP-L-glutamine to L-glutamate and cytidine diphosphoramidate [ 3 ] and is involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni [ 4 ].

1. Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12. FEMS Microbiol Lett 256, 318-23
2. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. J Biol Chem 280, 4602-8
3. Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni. Biochemistry 56, 6079-6082
4. Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni. J Biol Chem 282, 28566-76