InterPro domain: IPR044641

General Information

  • Identifier IPR044641
  • Description Sm-like protein Lsm7/SmG
  • Number of genes 349
  • Gene duplication stats Loading...

Abstract

The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [ 1 ].


1. Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex. Cell Res. 24, 497-500

Species distribution

Gene table

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