InterPro domain: IPR044609
General Information
- Identifier IPR044609
- Description Peptidyl-prolyl cis-trans isomerase FKBP2/11
- Number of genes 281
- Gene duplication stats Loading...
- Associated GO terms GO:0003755 GO:0061077 GO:0000413
Abstract
This entry includes FKBP2/11 and related proteins from bacteria, animals, fungi and plants. They are PPIases (peptidyl-prolyl cis-trans isomerases) that catalyse the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins [ 1 , 2 ].
1. The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 90, 5450-4
2. Profound redox sensitivity of peptidyl-prolyl isomerase activity in Arabidopsis thylakoid lumen. FEBS Lett 580, 3671-6
Species distribution
Gene table
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