InterPro domain: IPR044609

General Information

  • Identifier IPR044609
  • Description Peptidyl-prolyl cis-trans isomerase FKBP2/11

Abstract

This entry includes FKBP2/11 and related proteins from bacteria, animals, fungi and plants. They are PPIases (peptidyl-prolyl cis-trans isomerases) that catalyse the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins [ 1 , 2 ].


1. The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 90, 5450-4
2. Profound redox sensitivity of peptidyl-prolyl isomerase activity in Arabidopsis thylakoid lumen. FEBS Lett 580, 3671-6

Species distribution

Gene table