InterPro domain: IPR044601
General Information
- Identifier IPR044601
- Description 3xHMG-box protein HMGB6/HMGB13
- Number of genes 167
- Gene duplication stats Loading...
- Associated GO terms GO:0003677
Abstract
This entry represents a group of 3xHMG-box proteins (containing three copies of the HMG-box domain and a unique basic N-terminal domain), including 3xHMG-box1 (AT4G11080, also known as HMGB13) and 3xHMG-box2 (AT4G23800, also known as HMGB6) from Arabidopsis. Their three HMGâ€box domains and the basic Nâ€terminal domain contribute to DNA binding [ 1 ]. Their expression is induced in late G2 phase of the cell cycle, and upon nuclear envelope breakdown in prophase they rapidly associate with the chromosomes. Shortly after mitosis they are degraded and an Nâ€terminal destructionâ€box mediates the proteolysis. They may play a role in the organisation of plant mitotic chromosomes [ 2 ].
1. The plant-specific family of DNA-binding proteins containing three HMG-box domains interacts with mitotic and meiotic chromosomes. New Phytol 192, 577-89
2. Mitotic lifecycle of chromosomal 3xHMG-box proteins and the role of their N-terminal domain in the association with rDNA loci and proteolysis. New Phytol 208, 1067-77