InterPro domain: IPR044596

General Information

  • Identifier IPR044596
  • Description Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like
  • Number of genes 291
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004721  

Abstract

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) regulates phospholipid biosynthesis [ 1 ]. In mammals, it is a mitochondrial phosphatidylglycerophosphate (PGP) phosphatase that regulates cardiolipin biosynthesis [ 2 ].

This entry includes phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) and its homologues from animals and plants.In Arabidopsis there are two homologues, PTPMT1 and PTPMT2. They are involved in root growth and columella cells organization [ 3 ].


1. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. PLoS ONE 9, e93896
2. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 13, 690-700
3. Phosphatidylglycerophosphate phosphatase is required for root growth in Arabidopsis. Biochim Biophys Acta Mol Cell Biol Lipids 1863, 563-575

Species distribution

Gene table