InterPro domain: IPR044554

The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [ 1 ].

This entry represents APC subunit 2, which is a distant member of the cullin protein family that functions as a scaffold in SCF assembly [ 2 ].

1. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133, 653-65
2. CORRECTION. Plant Cell 31, 1386-1387