InterPro domain: IPR044542

Protein N(alpha)-terminal acetylation is one of the most common protein modifications in eukaryotic cells. This entry includes N-alpha-acetyltransferase 30 (NAA30), also known as Mak3, and related proteins. In budding yeast it's the catalytic subunit of the NatC Nalpha-terminal acetyltransferase [ 1 ]. Human NatC (hNatC) complex also contains the catalytic subunit hMak3 and the auxiliary subunits hMak10 and hMak31 [ 2 ]. However, Arabidopsis AtMAK3 function does not require NatC complex formation as in yeast [ 3 ].

1. NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J. Biol. Chem. 276, 20154-9
2. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Mol. Cell. Biol. 29, 3569-81
3. Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. Plant Cell 15, 1817-32