InterPro domain: IPR044526

This entry represents a group of heavy metal-associated plant proteins, including Protein SODIUM POTASSIUM ROOT DEFECTIVE 1/2/3 (NAKR1/2/3) from Arabidopsis. NAKR1, also known as NPCC6, is necessary for phloem function and root meristem maintenance [ 1 ]. It also promotes flowering through mediating FT (FLOWERING LOCUS T) translocation from leaves to shoot apices [ 2 ]. It also plays an important role in the regulation of FT expression under long-day conditions [ 3 ]. NaKR3 is involved in the salt stress response [ 4 ].

1. Arabidopsis NPCC6/NaKR1 is a phloem mobile metal binding protein necessary for phloem function and root meristem maintenance. Plant Cell 22, 3963-79
2. NaKR1 regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis. Nat Plants 2, 404-413
3. SODIUM POTASSIUM ROOT DEFECTIVE1 regulates FLOWERING LOCUS T expression via the microRNA156-SQUAMOSA PROMOTER BINDING PROTEIN-LIKE3 module in response to potassium conditions. Plant Cell Physiol 59
4. Overexpression of NaKR3 enhances salt tolerance in Arabidopsis. Genet. Mol. Res. 15, 16075