InterPro domain: IPR044522

This entry represents a group of CRC domain-containing proteins, including TSO1 and TCX2/3/4 from Arabidopsis. They are are homologues of the LIN54 DNA-binding components of the mammalian DREAM complex, a protein complex responsible for the regulation of cell cycle-dependent gene expression. TSO1 has been shown to regulate meristem organization and cell division [ 1 , 2 ]. It may transcriptionally represses MYB3R1 (a conserved cell cycle regulator), and together they coordinate cell proliferation with differentiation in shoot and root [ 3 ]. TCX3 (also known as SOL1) and TCX2 (also known as SOL2) have been shown to regulate fate transition and cell divisions in the Arabidopsis stomatal lineage [ 4 ].

1. Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats. Development 127, 2207-17
2. TSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis. Development 127, 2219-26
3. Arabidopsis TSO1 and MYB3R1 form a regulatory module to coordinate cell proliferation with differentiation in shoot and root. Proc Natl Acad Sci U S A 115, E3045-E3054
4. SOL1 and SOL2 regulate fate transition and cell divisions in the Arabidopsis stomatal lineage. Development 146