InterPro domain: IPR044520

This entry represents a group of plant ADP-ribosylation factor GTPase-activating proteins (ArfGAPs), such as AGD5/15 from Arabidopsis. ArfGAPs are a family of proteins containing an ArfGAP catalytic domain that induces the hydrolysis of GTP bound to the small guanine nucleotide-binding protein Arf, a member of the Ras superfamily of GTPases. AGD5 (also known as EVERSHED) is localised to the trans-Golgi network (TGN), where it co-localises with ARF1, a crucial GTPase that is involved in membrane trafficking [ 1 ]. It facilitates the intracellular movement of molecules required for organ abscission and fruit growth [ 2 ].

1. AGD5 is a GTPase-activating protein at the trans-Golgi network. Plant J 64, 790-9
2. HAESA and HAESA-LIKE2 activate organ abscission downstream of NEVERSHED and EVERSHED in Arabidopsis flowers. Plant Signal Behav 9, e29115