InterPro domain: IPR044518
General Information
- Identifier IPR044518
- Description ADP-ribosylation factor GTPase-activating protein AGD11/12/13
- Number of genes 394
- Gene duplication stats Loading...
- Associated GO terms GO:0005096 GO:0005543
Abstract
This entry represents a group of plant ADP-ribosylation factor GTPase-activating proteins (ArfGAPs), such as AGD11/12/13 from Arabidopsis. ArfGAPs are a family of proteins containing an ArfGAP catalytic domain that induces the hydrolysis of GTP bound to the small guanine nucleotide-binding protein Arf, a member of the Ras superfamily of GTPases. Of all known members belonging to the ARF-GAP protein family only AGD11, 12, and 13 possess a C2 domain enabling them to bind phospholipids, phosphoinositide and proteins in a calcium-dependent manner [ 1 ].
The C-terminal domain of AGD12 is structurally related to ENHANCED BENDING (EHB) 1, and both of them function as calcium-dependent proteins that affect gravitropism in Arabidopsis thaliana [ 2 ].
1. EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana. J Plant Physiol 206, 114-124