InterPro domain: IPR044510

General Information

  • Identifier IPR044510
  • Description CRIB domain-containing protein RIC1-like
  • Number of genes 571
  • Gene duplication stats Loading...

Abstract

The RIC (ROP-interactive CRIB motif-containing protein) family members act as Rho GTPase (Rop) targets that function in distinct Rop signaling pathways [ 1 ]. RICs interact with multiple ROP GTPases via their conserved CRIB motif, and link ROP proteins to diverse target molecules that bind to their variable domains [ 2 ]. RICs share several consensus amino acid residues upstream of the CRIB motif and a consensus PSWMXDFK block downstream of the CRIB motif. Unlike other group members, members of group V, consisting of RIC4 and RIC2, lack the PSWMXDFK block and contain a relatively long N terminus in front of the CRIB motif and a short C terminus [ 3 ].

This entry represents a group of plant CRIB domain-containing proteins including RIC1-11 (exclude 2 and 4) from Arabidopsis. They belong to the RIC (ROP-interactive CRIB motif-containing protein) family. RIC1 is inactivated by active ROP2 in the lobe-forming regions of pavement cells, which suppresses MT assembly, but promotes fine F‐actin assembly and thereby induces outgrowth of the region. In contrast, RIC1 is activated by active ROP6 in the neck‐forming regions of pavement cells, and then promotes the assembly of MTs, which limits the expansion of the region and results in the formation of a narrow neck. RIC1 also positively regulates the auxin effect and negatively regulates the ABA effect during root growth and lateral root development [ 3 ].

RIC7 functions as downstream effector of active ROP2 which is involved in the prevention of excessive stomatal opening upon light stimulation [ 4 ]. It is also involved in pollen tube growth regulation through its interaction with ROP1 [ 5 ].


1. A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-containing proteins that act as Rop GTPase targets. Plant Cell 13, 2841-56
2. Small GTPases: versatile signaling switches in plants. Plant Cell 14 Suppl, S375-88
3. Arabidopsis ROP-interactive CRIB motif-containing protein 1 (RIC1) positively regulates auxin signalling and negatively regulates abscisic acid (ABA) signalling during root development. Plant Cell Environ 36, 945-55
4. The Arabidopsis small G protein ROP2 is activated by light in guard cells and inhibits light-induced stomatal opening. Plant Cell 20, 75-87

Species distribution

Gene table