InterPro domain: IPR044443
General Information
- Identifier IPR044443
- Description 54S ribosomal protein L3, double-stranded RNA binding domain
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0003725
Abstract
MRPL3 (54S ribosomal protein L3) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL3 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM) [ 1 , 2 ]. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
This entry represents the DSRM of MRPL3 from fungi.
1. Structure of the yeast mitochondrial large ribosomal subunit. Science 343, 1485-1489
2. Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography. Nat Commun 6, 6019