InterPro domain: IPR044304

This family represents a group of proteins that bind and transfer iron-sulfur (Fe-S) clusters to target proteins and are required for Fe-S cluster assembly. They belong to the conserved family of P-loop ATPases. Iron-sulfur protein NUBPL, an IND1 homologue, is required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) [ 1 , 2 ]. Also included in this family is Fe-S cluster assembly factor HCF101 from Arabidopsis, which specifically assembles 4Fe-4S clusters and transfers them to the chloroplast PSI and ferredoxin-thioredoxin (FTR) complexes [ 3 , 4 ]. Iron-sulfur cluster carrier proteins APBC from Bacteria and Archaea are also included in this family [ 5 ].

1. Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol Cell Biol 29, 6059-73
2. The iron-sulphur protein Ind1 is required for effective complex I assembly. EMBO J 27, 1736-46
3. The universally conserved HCF101 protein is involved in assembly of [4Fe-4S]-cluster-containing complexes in Arabidopsis thaliana chloroplasts. Plant J 37, 174-85
4. Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly. Biochem J 425, 207-14
5. Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins. J. Bacteriol. 191, 1490-7