InterPro domain: IPR044294

This entry represents a group of lipases, including Lipid droplet phospholipase 1 (Lpl1) [ 1 ] and Rog1 from budding yeasts. This entry also includes some putative lipases, such as YDL109C/YDR444W from budding yeasts, C4A8.10 from fission yeasts and FAM135A/B from animals.

Lpl1 is a phospholipase involved in maintaining the lipid droplet morphology with broad substrate specificity [ 2 ]. Rog1 is a monoacylglycerol (MAG) lipase that regulates lipid homeostasis [ 2 ].

1. Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1842, 1383-92
2. ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. FEBS Lett. 589, 23-30