InterPro domain: IPR044288

General Information

  • Identifier IPR044288
  • Description E3 ubiquitin-protein ligase ZNF598/Hel2
  • Number of genes 214
  • Gene duplication stats Loading...
  • Associated GO terms GO:0061630   GO:0072344  

Abstract

This entry includes ZNF598 from animals and Hel2 from yeasts. They are RING finger ubiquitin ligases (E3) that play a key role in the ribosome quality control (RQC) [ 1 , 2 ]. Hel2 is involved ubiquitination and degradation of excess histones [ 3 , 4 ]. ZNF598 is associates with eukaryotic initiation factor 4E (eIF4E) homologous protein from mammalian (m4EHP) through binding to Grb10-interacting GYF protein 2 (GIGYF2). The m4EHP-GIGYF2 complex functions as a translational repressor and is essential for normal embryonic development of mammalian [ 5 ].


1. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Mol. Cell 65, 743-750.e4
2. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol. Cell 65, 751-760.e4
3. Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. PLoS ONE 7, e36295
4. Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways. EMBO J 38
5. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol. Cell. Biol. 32, 3585-93

Species distribution

Gene table