InterPro domain: IPR044283
General Information
- Identifier IPR044283
- Description Transcription factor FAMA/SPEECHLESS/MUTE
- Number of genes 453
- Gene duplication stats Loading...
- Associated GO terms GO:0010052 GO:0003700
Abstract
This entry represents a group of plant bHLH transcription factors, including FAMA, SPEECHLESS and MUTE from Arabidopsis. These proteins have been shown to play important parts in stomatal lineage development. SPEECHLESS (SPCH) generates stem cells and promotes their asymmetric division while MUTE regulates the meristemoid to Guard Mother Cell (GMC) transition. FAMA confers guard cell (GC) fate and is expressed at the equal division producing the two young GCs, but not in mature stomata [ 1 , 2 ].
SPCH can be regulated through phosphorylation by MAPK-mediated and BIN2 (BR INSENSITIVE2). It has been suggested that SPCH integrates brassinosteroid and stomata signalling pathways [ 3 ].
1. Transcription factor control of asymmetric cell divisions that establish the stomatal lineage. Nature 445, 537-40
2. Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes. Plant J 78, 566-77
3. SPEECHLESS integrates brassinosteroid and stomata signalling pathways. Nat Cell Biol 14, 548-54