InterPro domain: IPR044255

This entry includes Dr1 homologues from plants. They are putative transcription factors. Human Dr1 has been shown to interact with TATA-binding protein (TBP) and block its ability to activate transcription [ 1 ]. Arabidopsis Dr1 may affect the regulatory pathway for sexual development [ 2 ].

1. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70, 477-89
2. Cloning of cDNAs from Arabidopsis thaliana that encode putative protein phosphatase 2C and a human Dr1-like protein by transformation of a fission yeast mutant. Nucleic Acids Res 22, 5296-301