InterPro domain: IPR044241

This entry represents a group of thiol:disulfide interchange proteins, including TxlA from Cyanobacteria and HCF164 from Arabidopsis. HCF164 is a membrane-anchored thioredoxin-like protein that acts as a transducer of reducing equivalents in the thylakoid lumen. It contains a membrane-spanning sequence and a thioredoxin-like CXXC motif in the N- and C-terminal regions, respectively. The hcf164 mutant was found to be impaired in the stable assembly of the cytochrome b6 f complex within thylakoid membrane [ 1 ].

1. HCF164 receives reducing equivalents from stromal thioredoxin across the thylakoid membrane and mediates reduction of target proteins in the thylakoid lumen. J. Biol. Chem. 281, 35039-47