InterPro domain: IPR044232

This entry represents a group of plant UBX domain-containing proteins, including AtPUX1 from Arabidopsis. AtPUX1 regulates the hexameric structure and ATPase activity of AtCDC48, an essential AAA-ATPase chaperone that functions in numerous diverse cellular activities [ 1 ].

The UBX domain is comprised of ~80 amino acids and shares common secondary structure organisation with ubiquitin. In contrast to ubiquitin, UBX domains lack the C-terminal glycine motif necessary for covalent coupling to target proteins [ 2 ].

1. Protein domain-domain interactions and requirements for the negative regulation of Arabidopsis CDC48/p97 by the plant ubiquitin regulatory X (UBX) domain-containing protein, PUX1. J Biol Chem 282, 5217-24