InterPro domain: IPR044221

This entry represents a group of plant proteins, including DYAD from Arabidopsis and AMEIOTIC 1 from Zea mays (AM1) and Oryza sativa (OsAM1). DYAD, also known as SWITCH1, is required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis [ 1 ]. It may also be required for meiotic recombination initiation [ 2 ]. AM1 plays an important role in multiple early meiotic processes and may be required for the initiation of meiosis [ 3 ]. OsAM1 has a coiled-coil domain in its central region, it is required for the leptotene-zygotene transition step in meiocytes and plays an important role in the building the proper chromosome structure at the beginning of meiosis [ 4 ].

1. SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis. Genes Dev. 15, 1859-71
2. The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis. Development 130, 3309-18
3. Maize AMEIOTIC1 is essential for multiple early meiotic processes and likely required for the initiation of meiosis. Proc Natl Acad Sci U S A 106, 3603-8
4. OsAM1 is required for leptotene-zygotene transition in rice. Cell Res 21, 654-65