InterPro domain: IPR044219

This entry represents a group of plant alkaline ceramidases, including AtACER from Arabidopsis. AtACER is an alkaline ceramidase that hydrolyses ceramide to long-chain base (LCB). It is involved in sphingolipid metabolism, disease resistance, nutrient limitation, and response to salt stress [ 1 , 2 ].

1. The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance. Plant J. 81, 767-80
2. Loss of alkaline ceramidase inhibits autophagy in Arabidopsis and plays an important role during environmental stress response. Plant Cell Environ. 41, 837-849