InterPro domain: IPR044217

This entry includes a group of plant proteins, including CLPT1/2 from Arabidopsis. CLPT1/2 are accessory proteins regulating the assembly of the plastidial Clp protease system [ 1 , 2 ]. During assembly of the Clp proteolytic core, ClpT1 first binds to the P-ring (consisting of ClpP3-6 subunits) followed by ClpT2, and only then does the P-ring combine with the R-ring (ClpP1, ClpR1-4 subunits) [ 3 ]. CLPT1/2 share structural similarities to the N-domains of bacterial ClpA/C chaperones [ 3 ].

1. Assembly of the chloroplast ATP-dependent Clp protease in Arabidopsis is regulated by the ClpT accessory proteins. Plant Cell 23, 322-32
2. Structures, Functions, and Interactions of ClpT1 and ClpT2 in the Clp Protease System of Arabidopsis Chloroplasts. Plant Cell 27, 1477-96