InterPro domain: IPR044215

General Information

  • Identifier IPR044215
  • Description Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

Abstract

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIG-H, also known as Phosphatidylinositol-glycan biosynthesis class H protein) is part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyses the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis [ 1 , 2 ]. This entry also includes the PIG-H homologues from S. cerevisiae and S. pombe Gpi15 [ 3 ].


1. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J. 17, 877-85
2. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Mol. Biol. Cell 16, 5236-46
3. Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yeast 18, 1383-9

Species distribution

Gene table

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