InterPro domain: IPR044206

This entry represents a group of EG45-like domain containing proteins, including EGC1/2 from Arabidopsis and CjBAp12 from Citrus jambhiri. EGC2, also known as AtPNP-A, is an immunoreactant plant natriuretic peptide (irPNP) analog [ 1 ]. It shares some similarity with the cell wall loosening expansins but does not contain the carbohydrate-binding wall anchor. It signals via the second messenger cyclic guanosine 3',5'-monophosphate and modulates ion and water transport and homeostasis. It is secreted into the apoplastic space in response to stress and can enhance its own expression [ 2 ].

1. Expansin-like molecules: novel functions derived from common domains. J. Mol. Evol. 54, 587-94
2. Plant natriuretic peptides: systemic regulators of plant homeostasis and defense that can affect cardiomyoblasts. J. Investig. Med. 61, 823-6