InterPro domain: IPR044191

This entry includes a group of predicted chalcone--flavonone isomerases from plants, such as CHI3 (also known as CHIL, At5g05270) from Arabidopsis. It may function with TT5 to promote flavonoid production [ 1 ]. This entry also includes CHIL2 from Humulus lupulus (European hop). CHIL2 is involved in DMX (demethylxanthohumol) biosynthesis [ 2 ].

1. Role of a chalcone isomerase-like protein in flavonoid biosynthesis in Arabidopsis thaliana. J. Exp. Bot. 66, 7165-79
2. Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis. Proc Natl Acad Sci U S A 115, E5223-E5232