InterPro domain: IPR044186

This entry represents WOX4, a WUSCHEL-related homeobox protein from plants. Proteins in this family contain a sequence of eight residues (TLPLFPMH) downstream of the homeodomain called the WUS box. WOX4 is a transcription factor and part of the TDIF-TDR-WOX4 signaling pathway that plays a crucial role in the maintenance of the vascular meristem organisation during secondary growth [ 1 , 2 , 3 , 4 ].

1. Transcriptional regulatory framework for vascular cambium development in Arabidopsis roots. Nat Plants 25, 229-41
2. Pluripotent Pericycle Cells Trigger Different Growth Outputs by Integrating Developmental Cues into Distinct Regulatory Modules. Curr. Biol. 215, 642-657
3. WUSCHEL-RELATED HOMEOBOX4 (WOX4)-like genes regulate cambial cell division activity and secondary growth in Populus trees. New Phytol. 5, 1033-1042
4. Activation of ACS7 affects vascular development and demonstrates a link between ethylene synthesis and cambial activity. J. Exp. Bot.