InterPro domain: IPR044163

This entry includes SARED1 from Eschscholzia californica, and At5g02240, At2g37660 from Arabidopsis. This group of proteins evolved from a plant-specific branch of the ubiquitous Rossmann fold NAD(P)H/NAD(P)(+) binding reductases, with NADP-dependent epimerases or hydroxysteroid reductases as the most likely ancestors [ 1 ].

Sanguinarine (SA) belongs to a family of plant secondary metabolites called quaternary benzo[c]phenanthridine alkaloids (QBAs). SARED1 is a sanguinarine reductase that catalyses the reduction of benzophenanthridines, preferentially sanguinarine, to the corresponding dihydroalkaloids [ 2 ].

1. Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification. J. Biol. Chem. 285, 18397-406