InterPro domain: IPR044154

General Information

  • Identifier IPR044154
  • Description ADP-ribosylation factor-like protein 8A/8B

Abstract

This entry includes ADP-ribosylation factor-like protein 8A/8B (Arl8a/Arl8b) and related proteins. In animals, Arl8a and Arl8b are small GTPases that regulate axonal transport of synaptic vesicle proteins and lysosome motility [ 1 , 2 ]. Human Arl8a/Arl8b (also known as GIE2/GIE1) are required for chromosome segregation [ 3 ].


1. Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles. Neuron 99, 1216-1232.e7
2. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. J. Cell. Sci. 119, 1494-503
3. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. J. Cell. Sci. 117, 4705-15

Species distribution

Gene table