InterPro domain: IPR044150

This entry represents a domain found in class IV histone deacetylases ( 3.5.1.98 ), also known as histone deacetylase 11 (HDAC11) [ 1 , 2 ]. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation) [ 3 ]. HDAC11 and HDAC6 interact with each other in the cytoplasm and nuclei of APCs (antigen presenting cells) and are recruited to the IL-10 gene promoter to regulate its transcriptional activity [ 4 ].

In mammals, HDAC11 proteins are known to be involved in progression of various tumours. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients [ 4 ].

1. Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily. Nucleic Acids Res. 25, 3693-7
2. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277, 25748-55
3. Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene. Int. J. Mol. Med. 16, 589-98
4. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood 117, 2910-7