InterPro domain: IPR044121

General Information

  • Identifier IPR044121
  • Description Snu114, GTP-binding domain
  • Number of genes 131
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005525  

Abstract

Snu114 is a GTPase component of U5 snRNP, a spliceosome that catalyses the splicing of pre-mRNA to remove introns. It is thought that GTP hydrolysis by Snu114 induces conformational rearrangements in the spliceosome. Snu114 is homologous to EF-2, but typically contains an additional N-terminal domain not found in EF-2 [ 1 ].

This entry represents the GTP binding domain found in Snu114.


1. The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome. EMBO Rep. 3, 875-80

Species distribution

Gene table