InterPro domain: IPR044113

DDX41 interacts with several spliceosomal proteins and may recognise the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response [ 1 ]. DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Mutations of the DDX41 gene cause myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF) [ 2 ].

This entry represents the DEAD-box domain of DDX41. It contains the ATP-binding region [ 3 ].

1. The emerging roles of the DDX41 protein in immunity and diseases. Protein Cell 8
2. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. Cancer Cell 27, 83-89
3. Comparative structural analysis of human DEAD-box RNA helicases. PLoS ONE 5, 658-70