InterPro domain: IPR044096
General Information
- Identifier IPR044096
- Description Isoamylase 2, catalytic domain
- Number of genes 109
- Gene duplication stats Loading...
- Associated GO terms GO:0019252 GO:0019156
Abstract
This entry represents the catalytic domain found in plant Isoamylase 2 (ISA2), which is a Isoamylase-type debranching enzyme (ISA 3.2.1.68 ) that plays a major role in amylopectin synthesis. Arabidopsis contains three isoamylase-like proteins (AtISA1, AtISA2 and AtISA3) together with one LDA protein (AtLDA) [ 1 ]. In potato tubers, it has been shown that isoamylase is heteromultimeric and that two isoamylase proteins, ISA1 and ISA2, associate with each other to form a single isoamylase enzyme in vivo. The heteromultimeric isoamylase may function during starch synthesis to suppress the initiation of glucan molecules [ 2 ].
1. Arabidopsis mutants Atisa1 and Atisa2 have identical phenotypes and lack the same multimeric isoamylase, which influences the branch point distribution of amylopectin during starch synthesis. Plant J. 41, 815-30
2. Starch granule initiation is controlled by a heteromultimeric isoamylase in potato tubers. Proc. Natl. Acad. Sci. U.S.A. 101, 2215-20