InterPro domain: IPR043519

This entry represents the Pol beta-like nucleotidyltransferase (NT) superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. The following functional groups of nucleotidyltransferases have been included in this superfamily [ 1 ]:

• PolyA polymerases
• Protein nucleotidyltransferases, such as GlnD and GlnE
• CCA-adding enzyme
• Interferon-induced 2'-5' synthetase
• DNA polymerase beta and terminal deoxynucleotidyltransferase
• Antibiotic nucleotidyltransferases

1. DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. Nucleic Acids Res. 27, 1609-18