InterPro domain: IPR043358

GNL1, also known as HSR1, is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members [ 1 ].

This entry also includes Lsg1 from budding yeasts, LSG1-2 from Arabidopsis and Ns3 from fruit flies. Yeast Lsg1 is involved in 60S ribosomal subunit biogenesis [ 2 ]. LSG1-2 is required for 40S maturation [ 3 ]. Ns3 regulates insulin signaling and control body size [ 4 ].

1. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. Mamm. Genome 5, 100-5
2. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J. 24, 567-79
3. The 60S associated ribosome biogenesis factor LSG1-2 is required for 40S maturation in Arabidopsis thaliana. Plant J. 80, 1043-56
4. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev. 22, 1877-93