InterPro domain: IPR043322

General Information

  • Identifier IPR043322
  • Description C-terminal binding protein

Abstract

The transcriptional corepressor CtBP is a dehydrogenase with sequence and structural similarity to the d2-hydroxyacid dehydrogenase family. CtBP was initially identified as a protein that bound the PXDLS sequence at the adenovirus E1A C-terminal, causing the loss of CR-1-mediated transactivation. CtBP binds NAD(H) within a deep cleft, undergoes a conformational change upon NAD binding, and has NAD-dependent dehydrogenase activity [ 1 , 2 ].


1. Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol. Cell 10, 857-69
2. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays 23, 683-90

Species distribution

Gene table