InterPro domain: IPR043175

The F-actin capping protein (CP) is a heterodimer composed of two unrelated alpha and beta subunits. Neither of the subunits shows sequence similarity to other filament-capping proteins [ 1 ]. This superfamily represents the N-terminal domain of the beta subunit of F-actin capping protein. It is part of a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [ 2 ]. In Drosophila, mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration [ 3 ].

1. Beta-actinin is equivalent to Cap Z protein. J. Biol. Chem. 265, 8712-5
2. Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344, 352-4
3. Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration. Genetics 171, 1757-65