InterPro domain: IPR043169
General Information
- Identifier IPR043169
- Description Phosphomannomutase, cap domain
- Number of genes 167
- Gene duplication stats Loading...
Abstract
Phosphomannomutase (PMM) catalyses the conversion of mannose-6-phosphate to mannose-1-phosphate, an essential step in mannose activation and the biosynthesis of glycoconjugates in all eukaryotes [ 1 ]. Bacterial alpha-phosphoglucomutases share an overall fold similar to that of eukaryotic phosphomannomutases [ 2 ]. PMM can be divided into two domains: the cap and core. This entry represents the cap domain. The heart of the cap domain is a four-stranded antiparallel beta-sheet elaborated on one face with three alpha-helices [ 3 ].
1. Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. J. Mol. Biol. 363, 215-27
2. High-resolution structure of an atypical α-phosphoglucomutase related to eukaryotic phosphomannomutases. Acta Crystallogr. D Biol. Crystallogr. 69, 2008-16