InterPro domain: IPR043162
General Information
- Identifier IPR043162
- Description Dedicator of cytokinesis, C-terminal, lobe C
- Number of genes 119
- Gene duplication stats Loading...
Abstract
DOCK (dedicator of cytokinesis) proteins are potential guanine nucleotide exchange factors that activate some small GTPases, such as Rac, by exchanging bound GDP for free GTP [ 1 ]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis [ 2 ]. Nucleotide exchange is catalysed by a conserved catalytic DHR2 domain situated within the C-terminal region which consists of three lobes.
This entry represents lobe C of DHR2 which folds to form an antiparallel alpha-helical bundle [ 3 ].
1. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell. Sci. 115, 4901-13
2. DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. Blood 102, 2948-50
3. Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. J. Biol. Chem. 286, 25341-51