InterPro domain: IPR043160

Dyneins are microtubule-based AAA motor complexes that power ciliary beating, cell division, cell migration and intracellular transport. The motor domain comprises the AAA ring and three additional structural units: the linker, stalk/strut (both of which are major functional units of the heavy chain) and C-terminal domain. The C-terminal domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domains [ 1 ].

This entry represents the barrel region of the C-terminal domain of dynein heavy chain.

1. The 2.8 A crystal structure of the dynein motor domain. Nature 484, 345-50