InterPro domain: IPR042938

General Information

  • Identifier IPR042938
  • Description Phosphatidylinositol transfer protein Sfh5
  • Number of genes 1
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008526  

Abstract

In budding yeasts. Phosphatidylinositol transfer proteins (PITPs) are defined by their ability to transfer phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) monomers between membrane bilayers in vitro. The major PITP is encoded by SEC14. However, four other yeast SFH (Sec Fourteen Homologue) proteins designated Sfh2, Sfh3, Sfh4, and Sfh5, have been identified [ 1 ].

This entry represents Sfh5 from fungi. It has PtdIns transfer activity in vitro and may function in regulation of post-Golgi membrane trafficking events [ 2 , 2 ]. It is also involved in the organization of the actin cytoskeleton [ 3 ].


1. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol. Biol. Cell 11, 1989-2005
2. Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast. Traffic 6, 1157-72
3. A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast. Mol. Biol. Cell 20, 3583-97

Species distribution

Gene table

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