InterPro domain: IPR042815
General Information
- Identifier IPR042815
- Description Dynein regulatory complex protein 10
- Number of genes 4
- Gene duplication stats Loading...
Abstract
Dynein regulatory complex protein 10 (DRC10), also known as IQCD, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes [ 1 , 2 ]. It interacts with mammalian homologue of C. elegans uncoordinated gene 13 (Munc13) in spermatozoa and may participate in acrosome exocytosis [ 3 ]. I
1. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. Mol. Biol. Cell 24, 1134-52
2. Detailed structural and biochemical characterization of the nexin-dynein regulatory complex. Mol. Biol. Cell 26, 294-304
3. Corrigendum to: IQ motif containing D (IQCD), a new acrosomal protein involved in the acrosome reaction and fertilisation. Reprod. Fertil. Dev. 31, 1033