InterPro domain: IPR042575

General Information

  • Identifier IPR042575
  • Description Ubiquitin-associated protein 1, C-terminal
  • Number of genes 136
  • Gene duplication stats Loading...

Abstract

UBAP1 (ubiquitin associated protein 1) is a ubiquitin-binding ESCRT-I subunit (endosomal sorting complexes required for transport) [ 1 ]. The C-terminal region of UBAP1 is described as a solenoid of overlapping UBAs (SOUBA) which interacts with ubiquitin [ 2 ]. UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins.


1. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr. Biol. 21, 1245-50
2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure 20, 414-28

Species distribution

Gene table