InterPro domain: IPR042521

General Information

  • Identifier IPR042521
  • Description Dual specificity tyrosine-phosphorylation-regulated kinase
  • Number of genes 8
  • Gene duplication stats Loading...

Abstract

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer [ 1 ]. All DYRKs contain a conserved catalytic kinase domain preceded by the DYRK-characteristic DYRK homology (DH) box [ 2 ].


1. Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure 21, 986-96

Species distribution

Gene table