InterPro domain: IPR042491

Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [ 1 , 2 ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo [ 3 ]. Mutations in the Vps35 gene have been linked to Parkinson's disease [ 4 ]. Structurally, VPS35 forms a horseshoe-shaped, right-handed, alpha-helical solenoid [ 5 ].

This superfamily represents the alpha-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.

1. Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. Mol. Biol. Cell 12, 3242-56
2. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS Lett. 589, 1430-6
3. The retromer complex - endosomal protein recycling and beyond. J. Cell. Sci. 125, 4693-702
4. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N. Hum. Mol. Genet. 24, 1691-703
5. Functional architecture of the retromer cargo-recognition complex. Nature 449, 1063-7