InterPro domain: IPR042416

General Information

  • Identifier IPR042416
  • Description Oligosaccharyltransferase complex subunit OSTC
  • Number of genes 130
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008250   GO:0006486  

Abstract

The oligosaccharyltransferase complex catalyzes the transfer of oligosaccharide from a dolichol pyrophosphate donor en bloc onto a free asparagine residue of a newly synthesized nascent chain during the translocation in the endoplasmic reticulum lumen. OSTC, also known as DC2, is a oligosaccharyltransferase (OST) complex subunit. Together with KCP2, DC2 regulates the gamma-secretase-directed processing of amyloid precursor protein (APP) [ 1 ].


1. DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP). J. Biol. Chem. 286, 31080-91

Species distribution

Gene table