InterPro domain: IPR042303

This superfamily represents the C-terminal catalytic domain of Malonyl-CoA decarboxylase (MCD), enzyme which catalyzes the conversion of malonyl-CoA to acetyl-CoA and CO2 and is localized in peroxisomes, and more abundantly in the cytoplasm. MCD is found from bacteria to humans and it has important roles in regulating fatty acid metabolism and food intake. This catalytic domain shares unexpected structural homology to the GCN5-related N-acetyltransferase (GNAT) superfamily [ 1 ].

1. Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 21, 1182-92