InterPro domain: IPR042302

General Information

  • Identifier IPR042302
  • Description Ubiquitin-activating enzyme E1, FCCH domain superfamily
  • Number of genes 285
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Abstract

This domain is found in the ubiquitin-activating E1 (Ub-E1) family enzymes. It is one of the catalytic cysteine half-domains of Ub-E1. The catalytic cysteine half-domains contain the E1 active site cysteine, and are known as FCCH and SCCH, for 'first' and 'second' catalytic cysteine half-domain, respectively [ 1 , 2 ].

Structurally, the FCCH domain is composed of 7 anti-parallel beta sheets and 2 alpha helices.


1. Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes. Cell 134, 268-78
2. Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J Biol Chem 293, 18337-18352

Species distribution

Gene table

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