InterPro domain: IPR042272

General Information

  • Identifier IPR042272
  • Description ATP12, ATP synthase F1-assembly protein, N-terminal
  • Number of genes 140
  • Gene duplication stats Loading...

Abstract

This superfamily represents the N-terminal "wrist" domain of ATP12 ATPases which are required for the assembly of mitochondrial ATP synthase in all eukaryotes. The eukaryotic proteins include yeast Atp12 [ 1 ] and mammalian homologue ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2) [ 2 ], which are required for assembly of the mitochondrial F1-ATPase.


1. Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase. J. Biol. Chem. 266, 7517-23
2. Differential expression of ATPAF1 and ATPAF2 genes encoding F(1)-ATPase assembly proteins in mouse tissues. FEBS Lett. 551, 42-6

Species distribution

Gene table